Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Assessment of Vascular Changes in Animal Models of Retinal Degeneration and their Relationship to AMD

Seeliger M. W. 
Retinal Electrodiagnostics Research Group, Department II, University Eye Hospital, Tübingen

In animal models of retinal degeneration, in vivo imaging with a scanning-laser ophthalmoscope (SLO) provides direct morphological information if changes affect retinal vessels (Seeliger & Narfström 2000 a), the retinal pigment epithelium (RPE), or interfere with the optical properties of the retina that itself is not visible (Weber et al. 2002 b). Additional, indirect information can be obtained using fluorescent dye injections, subretinal vital stains, or local GFP production in gene therapy (Narfström et al. 2003 c). This presentation focuses on the assessment of vascular changes in mouse models of retinal degeneration. By means of fluoresceine and indocyanine green (ICG) angiography, it is possible to attribute the observed abnormalities to either the retinal or the choroidal circulation. The relevance of these findings for research on AMD will be discussed.
a) Seeliger MW, Narfström K. Functional assessment of the regional distribution of disease in a cat model of hereditary retinal degeneration. Invest Ophthalmol Vis Sci 2000; 41: 1998 –2005.
b) Weber BHF, Schrewe H, Molday LL, Gehrig A,White K, Sauer CG, Seeliger MW, Jaissle G, Friedburg C, Molday RS. Inactivation of the murine X-linked juvenile retinoschisis gene, Rs1h, suggests a role of retinoschisin in retinal cell layer organisation and synapse formation. Proc Natl Acad Sci USA 2002; 99: 6222-6227.
c)


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