Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Biocompatibility of AKKO-Gel – A New Deformable Biomaterial for Flexible Accommodative Intraocular Lenses

Al-Samir K.1, Zeitz O.1, Fell A.1, Kreiner C. F.2, Richard G.1, Uthoff D.3
1Dept. of Ophthalmology, Hamburg University; 2*Acri.Tec, Glienecke; 3Eye Clinic Kiel-Bellevue, Kiel

Purpose: Cataract surgery is the most common surgical procedure in ophthalmology. Up to now implantation of artificial intraocular lenses (IOL) is accompanied with a loss of accommodation. This leadt to the development of several concepts for accommodative IOLs. A new approach is to fill up the capsule after phacoemulsification with a deformable, gel-like material. In the present study the biocompatibility of AKKO-Gel, a new expandable polymeric material with these properties, is studied.
Method: Right eyes from 18 months old rabbits (n=7) of either gender underwent phacoemulsification. AKKO-Gel obtained from Acri.Tec, Glienecke, Germany, was filled into the capsule. A standard PMMA posterior chamber lens was implanted in 7 rabbits which served as controls. Animals were followed up for three months after surgery. The time-course of post-operative inflammation was judged clinically and was documented by photography. After three months scotopic and photopic electroretinogram (ERG) of the operated eye and for control purposes of the fellow eye was performed in 4 animals with AKKO-Gel- and 2 animals with standard PMMA-IOL. Function of the retinal pigementepithelium (RPE) was tested by recording of the c-w

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