|Programm||"Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"|
Effects of CD95L and Daunomycin on Retinal Function in Superfused Vertebrate Retina
Lüke M.1, Lüke C.1, Hueber A1, Walter P.1, Kirchhof B.1, Sickel W.2
Purpose: CD95L is a cytokine that triggers an intracellular cascade through CD95 receptor which mediates apoptosis in target cells. The combination of daunomycin and CD95L synergistically induces death of retinal pigment epithelial cells. Therefore, intravitreal application of daunomycin combined with CD95L could provide a therapeutic alternative for the treatment of proliferative vitreoretinopathy (PVR). In the present study we investigated the effects of daunomycin with and without CD95L on bovine retinal function.