Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Macular Pigment Density Subject to Different Stages of Age-Related Maculopathy

Jahn C., Wüstemeyer H., Brinkmann C., Trautmann S, Mößner A., Wolf S.
Dept. of Ophthalmology, Leipzig University

Purpose: Macular pigment (MP) is attempt to have a protective role in the development and progression of age-related maculopathy (ARM). We present results of measurements of macular pigment density (MPD) in patients with ARM at different stages with a modified confocal scanning laser ophthalmoscope (HRA, Heidelberg Engineering, Heidelberg, Germany).
Method: The ARM patients were categorized into 4 groups. The staging depended upon the size of drusen, geographic atrophy and loss of visual acuity due to AMD in the fellow eye; 1: drusen size <125µm, 2: drusen size <125µm, 3: drusen size <125µm + AMD in fellow eye, 4: drusen size <125µm + AMD in fellow eye. We took autofluorescence images at 488 nm and 514 nm with a modified HRA. MP density was evaluated within 2 degrees around the center of the fovea. In this study we included 146 patients with ARM, 26 in group 1, 19 in group 2, 80 in group 3 and 21 in group 4.
Results: The mean MPD of the different stages of ARM was in group 1: 0,205±0,092 D.U., group 2: 0,206±0,064 D.U., group 3: 0,200±0,076 D.U. and group 4: 0,197±0,073 D.U.. The statistical analysis (Kruskal-Wallis-test) showed no differences between the several groups.
Conclusions: Recent studies in ARM could not result significant differences of MPD between the various stages of ARM. Further longitudinal studies are requested to compare the incidenc

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