Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


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Abstract
Abstract

Comparison of Antibody Profiles from Brazilian and Swiss Patients with Ocular Toxoplasmosis

Garweg J. G.1, Sobottka-Ventura A.2, Flückiger F.1, Halberstadt M.1, Silveira C.3, Jacquier P.4
1
Dept. of Ophthalmology, University of Bern, Inselspital Bern, Switzerland; 2Dept. of Ophthalmology, Escola Paulista de Medicina, São Paulo, Brazil; 3 Clinica Silveira, Erechim, Rio Grande do Sul, Brazil; 4ParaDiag, Laboratory for Human Parasitology, Bern, Switzerland

Purpose: Our prospective study targeted to compare the specific immune response of individuals from Southern Brazil with active and presumably acquired ocular toxoplasmosis with that of a Swiss group of patients with presumably merely congenital disease.
Method: Aqueous humour (AH) and serum were drawn in parallel from the two collectives of patients presenting with active ocular toxoplasmosis. The clinical pictures of the Brazilian (n = 27) and Swiss (n = 50) groups were consistent with ocular toxoplasmosis. The infection could not be attributed to acquired or congenital origin in the majority of cases. Data are provided as medians (interquartile range=IQR), Mann Whitney U test was applied for statistical analysis, if not mentioned differently.
Results: Brazilian patients tended to be younger [33.0 (19.0) vs. 26.7 (12.6) years; p=0.065]. Total IgG in serum differed not [10.8 (2.7) vs. 11.1 (3.4) g/l (IQR); p=0.499] in contrast to AH [95 (195) vs. 20 (30) [mg/l (IQR); p=0.


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