Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"

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Online Autofluorescence Measurements during Selective RPE Laser Treatment (SRT)

Framme C.1, Schüle G.2, Roider J.3, Birngruber R.2, Brinkmann R.2 
1University Eye Hospital Regensburg, 2Medical Laser Center Luebeck, 3University Eye Hospital Kiel

Purpose: By using a train of microsecond laser pulses a selective RPE treatment (SRT) of macular diseases is possible while sparing the adjacent photoreceptors and avoiding scotoma. A problem is the non-visibility of the laser lesions due to a lack of thermal damage to the retina. Therefore invasive fluorescein-angiography is necessary to confirm RPE damage by leakage. It is supposed that the autofluorescent properties of the aging pigment lipofuscin, contained in the RPE cells, changes during laser treatment. The aim of the study was to evaluate the value of the autofluorescence changes as a non-invasive treatment control during selective RPE laser treatment.
Method: Selective RPE laser treatment was carried out by the use of a Nd:YLF laser (wavelength: 527nm; pulse duration: 1.7µs; repetition rate: 500 and 100Hz; spot size: 160µm; number of pulses: 100 and 30; energy: up to 130µJ) in in-vitro (porcine RPE sample) and during patient treatment. The fluorescent light from the RPE, which was decoupled from the laser light inside the slitlamp was detected by a photomultiplier or photodiode at wavelengths above 550nm. A multichannel spectral analysis of the fluorescent light was performed and the intensity of the RPE autofluorescence

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