Programm                 "Degeneration und Regeneration– Grundlagen, Diagnostik und Therapie"


Hotelbuchung
   Hotel Registration
Grußwort
   Welcome address
Beteiligte Gesellschaften
   Societies involved
DOG Information
   DOG Information
Eröffnung des Kongresses
   Opening Ceremony
Preise
   Awards
Ablauf der Tagung 2003
   General overview of congress
Lageplan der Räumlichkeiten
   Map of Congress Center
Wissenschaftliche Themen
   Scientific topics
Symposien
   Symposia
Wissenschaftliches Programm
   Scientific program
Posterpräsentationen
   Poster Presentation
Kurse
   Courses
Begleitende Veranstaltungen
   Accompanying program
Arbeitssitzungen
   Working sessions
Rahmenprogramm
   Social program
Allgemeine Informationen
   General Information
Autorenindex
   Index of Authors
Industrieaussteller
   Commercial exhibitors
Sponsoren
   Sponsors
Impressum



DOG Homepage


Abstract
Abstract

Neuroprotective Effect of Topical Administration of Brimonidine Purite in Rats with Laser-induced Chronic Ocular Hypertension

Banaskiewicz R.1, Vorwerk C. K.1, Ruiz G.2, Wheeler L. A.2, Wolde Mussie E.2 
1Department of Ophthalmologie, Otto-von-Guericke-University Magdeburg; 2Department of Biological Sciences, Allergan Inc., Irvine, CA

Purpose: One of the main characteristics in glaucoma is the progressive lost of retinal Ganglion cells (RGC). Therefore is the development of protective drugs for the RGC’s an important part in glaucoma research. The aim of this study was to examine the protective effect of topical administration of Brimonidine purite (Alphagan-P) in wistar-rats with laser-induced chronic ocular hypertension.
Method: Intraocular pressure (IOP) was elevated by laser photocoagulation of limbal and episcleral veins. Drug administration was begun on day 10-post laser treatment and continued for 21 days. Drug was applied twice a day in the laser treated eyes only. IOP was monitored weekly before and one hour after drug administration. The RGC’s were labelled by retrograde transport with Dextran- Tetra- Methyl- Rhodamine and counted in whole mounted retinas.
Results: Laser treatment caused a two- fold increase in IOP. The treatment with Brimonidine caused a clearly decrease in IOP. The RGC lost 10 days after IOP elevation was 17%. At the end of the experiment in the vehicle treated groups was a 41% decrease in RGC’s.  In Brimonidin


Zurück | Back